Reversing Tinnitus-Related Brain Changes
Key Takeaways Mice with noise-induced hearing loss developed hyperacusis-like symptoms, showing sustained brain hyperactivity to neutral sounds and abnormal arousal. This peripheral hearing damage distorted emotional sound processing in the amygdala, making the mice unable to distinguish between threatening and non-threatening sounds. Brief optogenetic stimulation of cortical inhibitory cells permanently reversed the brain hyperactivity, normalized…
